The Role of Systemic Immune-Inflammation Index in Severe Bicuspid Aortic Stenosis

Objectives: Bicuspid aortic valve (BAV) is the most common congenital cardiac abnormality and often leads to severe aortic stenosis (AS) at a younger age compared to tricuspid valves. Inflammation plays a key role in the pathogenesis of AS. This study aimed to investigate the association between the Systemic Immune-Inflammation Index (SII) and disease severity in patients with severe BAV-AS.Methods: In this retrospective observational study, 76 patients with severe BAV-AS and 76 age- and sex-matched controls without AS were included.

Routine laboratory data and transthoracic echocardiographic parameters were recorded. SII was calculated as platelet count × neutrophil count / lymphocyte count. The severity of AS was determined by aortic valve area (AVA) and mean transvalvular gradient. Correlation analyses, Receiver Operating Characteristic (ROC) curve, and logistic regression were used to assess the relationship between SII and AS severity.Results: The BAV-AS group had significantly higher SII values compared to controls (median: 931.7 vs.

534; P