Objective: Non-selective adrenergic alpha-1 antagonists have been shown to reduce arterial stiffness. Our aim is to assess the effects ofa selective adrenergic alpha-1 antagonist on arterial stiffness, namely silodosin.Patients and Methods: This prospective study was carried out on 20 patients with recently diagnosed benign prostatic hyperplasia(BPH).
International Prostate Symptom Score (IPSS) calculation, arterial stiffness test with an oscillometric device, and uroflowmetrywere performed prior to the planned silodosin medical treatment. After initial assessment, patients were given 8 mg of silodosin daily.Initial tests and calculations were repeated after 1 month of follow-up.
Comparisons between baseline and control data were performedusing the paired sample t-test and the Wilcoxon signed-rank test for normally and non-normally distributed data, respectively.Results: There was a significant reduction in the IPSS of patients after silodosin treatment (p