Monocyte-Derived Chemokines in Immune Thrombocytopenia: Diagnostic and Pathogenic Insights from a Cross-Sectional Case-Control Study

Aim: Immune thrombocytopenia (ITP) is an autoimmune disorder with incompletely understood immunopathogenesis. This study aimed to evaluate the serum levels of monocyte-derived chemokines—CCL1, CCL3, CCL4, and CCL16—in newly diagnosed ITP patients, with a focus on their potential diagnostic and pathogenic relevance.Material and Methods: In a cross-sectional case-control design, 84 patients with primary ITP and 84 age- and sex-matched healthy controls were included.

Serum chemokine concentrations were measured using ELISA.Results: CCL4 levels were significantly elevated in ITP patients (p