Dandy-Walker malformation is a rare congenital anomaly of the posterior fossa of the skull and cerebellum. The pathology includeshypoplasia or agenesis of the vermis of the cerebellum, cystically dilated fourth ventricle, and an enlarged posterior fossa of the skull.This anomaly of the cerebellum can lead to a wide spectrum of clinical presentations ranging from mild developmental delay to severehydrocephalus, seizures, and fatality.
It is usually diagnosed prenatally using anomaly scans. A detailed study of morphological andmicroscopic findings is necessary for a better understanding of the etiopathogenesis of this anomaly.Autopsy is considered the gold standard for confirmation of findings associated with this anomaly. It can also help to explore otherassociated anomalies which can further help in genetic studies and patient counseling.Herein, we present an autopsy report of a 20-week-old male fetus with Dandy-Walker malformation diagnosed prenatally and sent forautopsy with informed consent after medical termination of pregnancy.
Gross and microscopic findings were studied and comparedwith those of previous studies done in the past.